He began his career with radio shows in New York City and Chicago before being enticed to come to then-radio station WCPO in Cincinnati as a news reporter and announcer around 1945.

Eventually abandoning radio news in favor of entertainment, he spent his first few years in television as host of Paul Dixon's Song Shop, a three-hour daily show he co-hosted with Dottie Mack and Wanda Lewis pantomiming to records of the day.

[citation needed] On Tuesday, March 11, 1969, he staged a wedding for two rubber chickens that had become longtime props on the show (they were mainly used for in-studio commercials for Kroger).

Former late night TV host David Letterman, who grew up in Indianapolis, cited Dixon's comedic talent as inspiration for his own antics.

Personal complications later led to a ruptured aneurysm, which claimed Paul's life on December 28, 1974; his funeral was broadcast live over the stations in the Avco network that carried his show.