Paul Guttmann (9 September 1834 in Ratibor (Polish: Racibórz) – 24 May 1893 in Berlin) was a German-Jewish pathologist.
In 1879 he replaced Heinrich Curschmann (1846-1910) as director of the Moabit Hospital, where one of his students was pediatrician Hugo Neumann (1858-1912).
He is remembered for work with neurologist Albert Eulenburg (1840-1917) involving research of the sympathetic nervous system.
With Eulenburg he published Die Pathologie des Sympathicus auf physiologischer Grundlage, a work that was considered at the time to be the best written book on the pathology of the sympathetic system from a physiological basis.
With Paul Ehrlich (1854-1915), he discovered that the histological stain, methylene blue had effectiveness against malaria.