Paul Henry Guzzi (born June 17, 1942) is an American businessman and former Massachusetts Secretary of the Commonwealth.

He was president and chief executive officer of the Greater Boston Chamber of Commerce for 19 years.

In 1978, Guzzi ran for the United States Senate, he was defeated in the Democratic primary by Paul Tsongas.

In 1980 Guzzi was named interim chancellor of the newly formed Massachusetts Board of Regents for Public Higher Education.

[6] Guzzi is also a trustee of the Citi Performing Arts Center[7] and a director of The Boston Foundation.