[1] Konerko had been on the radar of Eddie Bane, the special assistant to Dodgers general manager Fred Claire, since he was 13 years old.

[6] Konerko played for the Triple-A Albuquerque Dukes for the majority of the 1997 season, batting .323 with 37 home runs and 127 RBI in 130 games.

[10] On July 4, 1998, Konerko was traded along with left-handed pitcher Dennys Reyes to the Cincinnati Reds for All-Star closer Jeff Shaw.

[12] Konerko became a consistent hitter and power threat upon his arrival to the White Sox, hitting for a .294 average with 24 home runs and 81 RBI in 142 games during his first season with Chicago in 1999.

[13] Konerko made his first postseason appearance that year, when the White Sox lost to the Seattle Mariners in the 2000 American League Division Series (ALDS).

[14] In the 2002 All-Star Game, Konerko hit a two-run double for the American League in the top of the seventh inning to grab the lead.

[15] Konerko suffered a thumb injury in 2003 that reduced his playing time to 137 games and resulted in a drop in offensive production.

[10] Konerko continued hitting hot into the playoffs with a home run in Games 1 and 3 of the ALDS against the Boston Red Sox.

[23] He was named the ALCS MVP on the strength of a .268 batting average, two home runs and seven RBI, becoming the first, and as of the 2023 season, only White Sox player to receive the award.

[24] He said, "I think you could split this four ways", referring to his feeling that the MVP should be awarded to the White Sox starting pitchers who pitched four consecutive complete games in the ALCS.

Those were Konerko's only RBIs of the World Series, but they were critical in giving the White Sox the momentum to complete a four-game sweep of the Houston Astros.

[10] On September 18, 2008, Konerko became the last opposing player to hit a home run at Yankee Stadium[28] in the ninth inning of a 9–2 White Sox loss.

Konerko and the White Sox defeated the Minnesota Twins in a dramatic 1–0 victory in the tie-breaker game to decide the AL Central winner and move on to the playoffs.

On July 10, 2010, Konerko was announced to replace Twins first baseman Justin Morneau at the 2010 Major League Baseball All-Star Game.

White Sox pitcher Mark Buehrle returned the favor in the next inning hitting Twins first baseman Michael Cuddyer.

Refusing to leave the game, Konerko hit a solo home run on the first pitch he saw in his next at bat against Pavano.

[33] Konerko finished the 2010 season with 39 home runs, his most since 2005 and the third-highest total of his career, as well as a .312 average and 111 RBI in 149 games.

In November 2011, Konerko was inducted into the Arizona Fall League Hall of Fame along with Phillies first baseman Ryan Howard.

[45] On July 1, 2012, Konerko was elected by his peers, along with teammates Adam Dunn, Jake Peavy and Chris Sale to the 83rd All-Star Game in Kansas City.

[47] Throughout the 2014 season, Konerko was honored and given a variety of farewell gifts during road games from various teams throughout baseball, including the Twins, Yankees, Indians, Royals, and crosstown rival Cubs.

Konerko went 2-for-3, including a bases-clearing three-run double in the bottom of the fifth inning to put the Sox in the lead for good as they went on to win 8–3.

[51] During the final homestand of the season, Konerko was honored during a pregame ceremony on September 27, 2014, before a game against the Kansas City Royals.

Konerko went 0-for-3 before being replaced in the top of the sixth inning by Andy Wilkins and leaving the field to a standing ovation from the crowd of 32,266.

[53] Upon his retirement, Konerko finished in the top three in most offensive categories with the White Sox with 432 home runs (second), 2,292 hits (third), 1,383 RBIs (second), 406 doubles (third), and 4,010 total bases (first).

He does a good job with it and brings guys along for the ride.”[54] Konerko retired on September 28, 2014 after spending 18 years in the Major League Baseball, the last 16 of which were with the White Sox.

[52][56] On October 24, 2014, Konerko was named the co-winner of the Roberto Clemente Award, sharing the honor with Jimmy Rollins of the Philadelphia Phillies.

[57] On May 23, 2015, prior to a game against the Minnesota Twins at U.S. Cellular Field, Konerko became the tenth White Sox player to have his number retired.

[10] In 2020, his first year of Hall of Fame eligibility, Konerko received 2.5% of votes, below the 5% threshold, and has been subsequently removed from future ballots.