Maguire attended Ursuline High School in Youngstown, Ohio where he was an All State wide receiver and punter; he also played basketball and ran track.

He played tight end at The Citadel where he led the nation in touchdown receptions his senior season in 1959 and was named a 3rd Team Associated Press All American; he was recruited by Assistant Coach Al Davis, the future Oakland Raiders owner.

During the time he was at ESPN, Maguire called playoff games for ABC every year except for 2002, when the network elected to use Brent Musburger and Gary Danielson, its lead college football broadcast team, on Wild Card Saturday.

Maguire, who had a residence in Buffalo after his playing days, hosted a locally produced call-in show called the "Budweiser Sportsline".

Maguire worked his last regular season NFL game on January 1, 2006, as the St. Louis Rams and Dallas Cowboys played on ESPN's final Sunday night broadcast.

However, Maguire was retained by ESPN to serve as a commentator for ABC's college football with Brad Nessler, former Miami Dolphins quarterback Bob Griese, and field reporter Bonnie Bernstein.