Worrilow was redshirted his first year due to a defensive scheme change, and ultimately turned down interest from the Arkansas Razorbacks[1] to return to Delaware in the spring of 2008 and walk on the Blue Hens football squad.

Worrilow immediately drew attention during his first spring at Delaware, earning a starting spot the following fall as a redshirt freshman along with a team scholarship as a walk-on.

[5] Notable performances include two-time consecutive fumble recoveries for touchdowns (a current Delaware record), a career-record 18 tackles in the Route 1 Rivalry game against Delaware State, which earned him the College Sports Madness CAA Defensive Player of the Week, Beyond Sports Network Defensive All-Star and the Nate Beasley Game MVP Award,[6] and a 38-stop run through the four-game 2010 FCS playoffs, leading the Blue Hens to the 2010 NCAA Division I Football Championship in Frisco, Texas, where they lost 20–19 in a match to Eastern Washington.

Worrilow was signed as a free agent after the 2013 NFL draft by the Atlanta Falcons eventually making the final 53-man roster for the 2013 season.

[8] Worrilow ended the 2013 NFL season as the Falcons' leading tackler, landing him a spot on Mel Kiper, Jr.'s All-Rookie Team alongside teammate and fellow rookie Desmond Trufant.

[12] In the 2016 season, Worrilow and the Falcons reached Super Bowl LI, where they faced the New England Patriots on February 5, 2017.

Despite Worrilow's great success in high school, he was not offered a single scholarship to play NCAA Division I football.

[31] In the spring of 2011, Worrilow discovered he had been matched to a 23-year-old female leukemia patient in need of a life-saving peripheral blood stem cell donation.

[33] In the five days leading up to the procedure, Worrilow underwent a series of injections of a drug called filgrastim to increase the number of blood-forming cells in his bloodstream.