[1][2] De Vos's research is strongly focused on biomedical application of carbohydrates and their effects on immunity and metabolism.

His research findings are applied to improve biomaterials for application in bioartificial organs and to influence immunity in consumers of carbohydrates.

[7] De Vos is the principal investigator and project leader in the Carbohydrate Competence Center (CCC),[8] Fascinating[9] and the juvenile diabetes research foundation (JDRF) funded "encapsulation consortium".

[10] In addition to being a scientist, de Vos is a well-known kynologist, dog-handler and trainer and writer of three Dutch books about welfare and training of gundogs.

[11] The books are titled: Wat een jachthond moet weten, Apporteren, and Emoties bij honden.