She starred in a number of television series, most notable the ABC police drama Women's Murder Club (2007–08), and had recurring roles on NYPD Blue, NCIS, Barry, and Chicago Med.
[3] She went on to guest star in a number of notable television series, include Chicago Hope, Law & Order, Ally McBeal, Dharma & Greg, NYPD Blue, ER, Heroes, and Criminal Minds.
In film, Newsome has appeared in Guess Who (2005), Little Miss Sunshine (2006), Reign Over Me (2007), Things We Lost in the Fire (2007), Thinspiration (2014), Black or White (2014) and Spider-Man: No Way Home (2021).
From 2007 to 2008, she starred alongside Angie Harmon, Laura Harris and Aubrey Dollar in the ABC police drama Women's Murder Club playing medical examiner Claire Washburn.
[5] The following years, she returned to playing guest-starring roles, appearing on The New Adventures of Old Christine, Bones, Parenthood, FlashForward,[6] Drop Dead Diva, Grey's Anatomy, Suits, Castle, and most notably How to Get Away with Murder opposite Viola Davis, for which she received positive reviews.