Paulina (died c. 397) was a late Roman aristocrat and philanthropist, who was the wife of Pammachius and the daughter of Paula of Rome.

[5][6] She is depicted in part of the mural with her arms outstretched in welcome, with a figure, who is possibly her sister Rufina stood nearby.

[10] Pammachius and his friend Fabiola established a xenodochium in Paulina's honor, which provided hospitality to travellers on the river Tiber.

[13] He also wrote, in Epistle 66, discussing the alms which Pammachius dispensed, that: "Other husbands sprinkle violets, roses, lilies, and shining blossoms and alleviate the pain in their hearts by these good offices.

[15] Gunhild Vidén discusses Paulina's removal of her clothing after her conversion, as a depiction of her change from pleasure-seeking to a life of virtue.