He was descended from a noble Byzantine family, who fled to areas under the control of the Venetian Republic after the Fall of Constantinople.

[2] After returning to Corfu, he participated in creating an "Academy of Sciences", sponsored by the French government.

[1] When Corfu became a protectorate of the British Empire in 1815, Lord High Commissioner Thomas Maitland transformed the school into the "Public Academy of Fine Arts".

[3] In 1824, when Lord Guilford created the Ionian Academy, Prosalentis was one of the first to be offered a teaching position there.

[2] In addition to his own sculpting, he also made sketches for works by other sculptors and pedestal panels for several monuments and busts.