Paxinos is a census-designated place in Northumberland County, Pennsylvania, United States.

[1] It has a post office with the zip code 17860.

[2] In 2010, the population was 2,467 residents.

[3] Paxinos was founded in 1769 and was named for a Swanee Native American chief, according to its Pennsylvania Keystone Marker.

The town is known in the area for its music store, which has a distinctive mural of a guitar player.