Paxton Creek is a 13.9-mile-long (22.4 km)[3] tributary of the Susquehanna River in Dauphin County, Pennsylvania in the United States.

[4] The name Paxton, or Paxtang, is derived the Susquehannock term "Peshtank", meaning "where the waters stand" or "the place of springs".

It is born from two branches on the southern slopes of Blue Mountain to form the main stem in Lower Paxton Township.

[5] Later, it extends downstream approximately 6.2 miles to Harrisburg as a concrete channel built in 1914 (against the wishes of Warren Manning) to mitigate urban runoff and flooding, which is common after severe storms.

[6] Where the stream passes through the city it receives the discharges from several large sewers, which, during dry weather, pollute the water and foul the shores and bottom of the creek to a very objectionable extent.