In addition to the permanent contemporary art collection, the centre includes a sculpture garden and a space designated to the installation of temporary exhibitions.

The collection includes over 1000 works by more than 300 artists, among which sculptures, installations, environments, paintings and videos made from the 1950s to the present, mostly acquired as the result of the exhibitions organized by the center.

Several recent European pieces of art have been acquired thanks to the Friends of the Museum and the Cassa di Risparmio Bank Foundation of Prato.

The collection includes works by Vito Acconci, Nobuyoshi Araki, Stefano Arienti, Marco Bagnoli, Rossella Biscotti, Botto & Bruno, Paolo Canevari, Loris Cecchini, Enzo Cucchi, Jan Fabre, Lucio Fontana, Marco Gastini, Piero Gilardi, Dmitry Gutov, Emilio Isgrò, Ilya Kabakov, Anish Kapoor, Jannis Kounellis, Barbara Kruger, Francesco Lo Savio, Sol LeWitt, Philip-Lorca di Corcia, Eliseo Mattiacci, Fausto Melotti, Mario Merz, Liliana Moro, Robert Morris, Ugo Mulas, Bruno Munari, Vik Muniz, Maurizio Nannucci, Hermann Nitsch, Julian Opie, Anatolij Osmolovskij, Mimmo Paladino, Giulio Paolini, Gianni Pettena, Michelangelo Pistoletto, Anne e Patrick Poirier, Remo Salvadori, Julian Schnabel, Daniel Spoerri, Mauro Staccioli, Superstudio, David Tremlett, UFO, VALIE EXPORT, Massimo Vitali, Yelena & Viktor Vorobyev, Erwin Wurm, Gilberto Zorio.

Contributions to the foundation of the centre were made by the Prato town council, private companies and members of the public.