From there, he led multiple campaigns further north in 1775 and 1776 to establish Spanish control over the area and pushing the Apaches further west.

The name of the community and the surrounding municipality, adopted in 1866, is in honor of General Pedro Meoqui Mañon, a military leader from the city of Mexico.

In 1864, when Meoqui Mañon was a colonel, he escorted Benito Juárez from Monterrey to Chihuahua, passing through the community en route.

In 1866, Juárez returned to the community and decided to consecrate the community - a town located about an hour from the state capital of Chihuahua - as the Villa of General Pedro Meoqui Mañón (colloquially referred to as "Meoqui") on December 11 as a tribute to his faithful friend who was cruelly murdered on August 8, 1865, in Hidalgo del Parral in the Battle of Parral against the French invasors.

The abigeo stew is another distinguished dish, made with dried meat and red chili sauce originated by Col. Lázaro Cárdenas.