A staunch anti-Jesuit, one of the biggest foes of the Society of Jesus, Campomanes was the main driving force behind their expulsion from the Spanish Empire.

On the death of his father, his mother entrusted his upbringing to an uncle connected to the Collegiate church of Santillana del Mar.

An avid learner, he was especially interested in history, economics, philology, and studied ancient and modern languages, including Arabic.

His detailed work contains a collection of royal ordinances and edicts regarding the encouragement of arts and manufactures, and the introduction of foreign raw materials.

[10] From 1788 to 1793 he was president of the Council of Castile; but on the accession of Charles IV he was removed from office, and retired from public life.

Don A Rodriguez Villa has placed a biographical notice of Campomanes as an introduction to the first edition of his Callas politicoeconomicas, published in 1878.