Pedro Ruiz de Villegas y Cevallos II (b. Burgos, c. 1304 – Medina del Campo, 1355) was a Spanish noble baron in the service of the Kingdom of Castile and a member of the Order of Santiago.
As the majorat of his own heraldic crest, he received titles over Villegas, Manquillos, Castillo Pedroso, Moñux, Pedrosa del Páramo, Manciles, Valdegómez and the palace of Sasamón.
For his service in the First Castilian Civil War, and his role in the destruction of the Blanche of Bourbon league he received the castle of Caracena, and was named high adelantado of Castile in 1354.
On March 19, 1351, Pedro and Teresa sold most of their properties to their paternal uncle, Garci Lasso de la Vega II.
In April of the same year, by mandate of the King, Pedro Ruiz de Villegas II was assassinated while he slept along with his squire in the village of Medina del Campo.