[16] Warner's review of the second volume applauds the book "that can have you laughing out loud at something outlandish one moment, then shock or even disgust you with its vivid depravity the next, and yet it never feels disjointed in the least".

[18] Katherine Dacey criticizes the satire stating that it is "seldom generous or polite, but it shouldn't be punitive, either, and that’s Peepo Choo's greatest shortcoming".

[21] Luster's review of the second volume commends Smith's artwork, stating "His art continues to infuse Spümcø expressions and animated movement with a more traditional manga style, just short of including his very own version of the "gross-up close-up"".

[23] Ed Sizemore criticizes Smith's writing for "[having] all the subtlety of a brick to the face", comparing it to South Park and Family Guy.

[25] ICv2's Steve Bennett states "Milton is naturally everyone's favorite pinata but no one escapes being pilloried; Smith seems to have equal contempt for the fans of both manga and superhero comics".

[26] Anime News Network's Lissa Pattillo commends the manga its "great cultural commentary showing the same story played out through very different eyes and circumstances; an in-your-face charisma that's never short of memorable and an overall package that definitely qualifies as unique" but criticizes it for the "different elements of story don't mesh well together and as a result the switching back and forth between leaves them both feeling neglected in the end; sheer amounts of sex and violence can be too over the top".