The region encompasses the current towns of Brunswick, Topsham and Harpswell, Maine in Sagadahoc and Cumberland counties and was first settled by English settlers in 1628.

The word Pejepscot has its roots in the Wabanaki language and has different translations (long, rocky rapids part and crooked like a diving snake).

[1] in the year 1620, a charter was granted by King James II of England to forty noblemen, knights, and gentlemen, calling themselves the Plymouth Company.

On June 16, 1632, the Plymouth Company granted a patent to Purchase and his brother in-law George Way for the lands at Pejepscot, in the current towns of Brunswick, Topsham and Harpswell Maine.

On August 22, 1639, purchase made a legal agreement with John Winthrop, Governor of Massachusetts, placing his land under the jurisdiction of that colony.

[6] In 2020 the Merrymeeting Bay Pioneers Project found a 17th-century dwelling in a field at the Hunter Farm on Foreside Road in Topsham.