Later in the 20th century, the auto mechanic and other show classrooms were removed from the annex and converted to modern computer laboratories and art rooms.

[1] Pelham Memorial High School students take a college preparatory curriculum that includes several mandatory classes for graduation.

[6] Pelham currently offers Advanced Placement courses, with the intention of adding more as the budget allows.

Also, as AP Chemistry has a reputation in the school for being the most difficult class at Pelham, it is only offered once every two years due to the lack of students willing to take it.

[8] The Social Studies Department provides courses which follow the New York State Core Curriculum.

At the culmination of the two-year Global History and Geography Courses the respective regents exam is taken, typically in tenth grade.

For students taking AP United States History, a concurrent Political Process Seminar is given in podcast form to satisfy the government requirement for graduation.

Otherwise, students may take any of the Participation in Government, American Law, Criminal Justice, Sociology, or Politics and Public Policy courses as a senior to complete the requirement.

[8] The Pelham Mathematics Department has undergone changes as a result of the Board of Regents restructuring its standardized exams.

Qualified eighth grade students are given the opportunity to take Integrated Algebra Honors to put them on the accelerated track.

During the 2011–12 school year, a Science Research pilot program was offered, allowing students to improve their statistical abilities for competition.

[9] In the spring of 2018, the Jazz Ensemble began to participate in NYSSMA Majors and received a silver rating.

[8] The Science Research Department is a four-year elective program situated in the school's Biotechnology Laboratory.

This teaches students how to adequately prepare reagents, perform sterilization exercises, run and maintain a biotechnology laboratory.

Students also are instructed in various molecular biology techniques, such as DNA amplification via polymerase chain reaction, restriction enzyme analysis, and bacterial culture, identification, and transformation.

Students have previously been named semifinalists and region finalists, winning college scholarship money.

Teacher Steven Beltecas has played a critical role in improving the school's performances at these competitions.

Modern foreign languages include French, Spanish, and Italian I II and III.

Students often take a two-year sequence of one language as seventh and eighth graders, which counts as one credit on their high school transcript.

Pelham Memorial High School's Knight and Lamp Chapter of the National Honor Society is guided by the four principles of scholarship, leadership, character, and service.

The Italian Honor Society is the Vittorio Emmanuele Chapter of the Società Onoraria Italica.

Sock 'n' Buskin is a theater troupe within the school, nominated annually by the National Youth Arts Awards for their plays and musicals.

The theatre program has produced three winners of The Roger Rees Awards: Sarah Liddy (2014), Meredith Heller (2020), and Liam Ginsburg (2022).

Then, at the end of the day, the grades each perform their Silly Walk skit in front of the rest of the school.

The points from decorations, events, attendance, the canned food drive, and the Silly Walk are then totaled and a winner is declared.

The Haunted House is a student association-organized fundraiser event that takes place in October.

It involves the senior class, each wearing Halloween-themed outfits and makeup, being stationed in rooms throughout the high school, that are decorated accordingly.

The field hockey team also won the section against Mamaroneck, a three-time state winning high school in the last 20 years, in 2020.