[1] She was appointed to the National Assembly of Botswana in 1999 as one of the four specially selected members and was re-elected in the 2004 general elections.

On 17 December 2018, Venson-Moitoi announced that she would contest the party presidency.

On 5 April 2019 she wrote a letter to Secretary General of the Botswana Democratic Party stating that she was withdrawing from the presidential election, alleging that the election was "rigged from the beginning.

"[6] The previous day, the High Court had ruled against her request to have the elective congress postponed, agreed with opposition lawyers that she had not proved if her citizenship was by birth or descent.

[6] Her candidacy had been supported by former President Ian Khama, who slammed the ruling party, accusing them of "cheating, intolerance and intimidation.