As a 501(c)(3) not-for-profit organization, Pelotonia facilitates all of riders' and fundraisers' donation money contributing to cancer research, while corporate and philanthropic partners fund the administrative staff and functions.

[2] That summer, Caligiuri and Tom Lennox, cancer survivor and Abercrombie & Fitch executive, rode together in the Pan-Massachusetts Challenge (PMC).

[4] The institute was launched with a five-year plan for talent recruitment, fundraising, publication, and streamlined deployment of immunotherapies in cancer treatment.

[8] Nearing the end of his third Pelotonia ride, 27-year-old Ohio State medical student Mason Fisher suffered a cardiac event on August 6, 2022.

[11] In 2018, it was discovered by friends and fundraising supporters, that John Looker, a prominent Pelotonia participant for at least seven years, was not battling cancer as he had claimed.

Upon learning that Looker had confessed to his deception, Pelotonia officials brought this to the attention of the Columbus Police Department and the Ohio Attorney General's office.

To participate in Pelotonia, riders sign up to bike one of several possible distances, ranging from 25 to 200 miles, with ascending mandatory minimum fundraising goals.