Peltosaurus is an extinct genus of anguid lizard from North America that lived from the Eocene to the Miocene.

The type species Peltosaurus granulosus was named in 1873 by American paleontologist Edward Drinker Cope.

In 1955 a new species, Peltosaurus macrodon, was named from the Eocene of California.

Lizard bones from the Late Miocene of Nebraska were attributed to a new species of Peltosaurus called P. minimus in 1976, extending the fossil range of Peltosaurus and Glyptosaurinae into the Neogene.

[1] However, these bones were later referred to a genus of skinks called Eumeces, meaning that the fossil range of Peltosaurus and Glyptosaurinae does not go beyond the Paleogene.