Pelutho is a hamlet in the civil parish of Holme St. Cuthbert in Cumbria, historically in Cumberland, England.

In the past, the name has been written in several different forms, including Pellathow, Pellothoe, Pollathow, Pellithow, and Pelato.

A series of milefortlets were constructed beyond the western end of Hadrian's Wall to defend against incursions across the Solway Firth.

Two of these, milefortlets 13 and 14, are located within 2 miles (3 kilometres) of Pelutho, near the hamlets of Blitterlees and Beckfoot respectively.

No public transport services are available in Pelutho; the nearest railway station is at Aspatria, 5.5 miles (9 kilometres) to the south-east, and the nearest bus stop is at Beckfoot, 3.5 miles (6 kilometres) away by road.