In August 2017, the campus established on-campus housing for the first time with the opening of Orchard Hall, a 250-bed dormitory.

[2] The Penn State–Brandywine athletic teams are called the Nittany Lions.

The campus competes as a member of the Division III ranks of the National Collegiate Athletic Association (NCAA), primarily competing within the United East Conference since joining in the 2024–25 academic year.

Men's sports include baseball, basketball, cross country, golf, soccer, and tennis; while women's sports include basketball, cross country, soccer, softball, tennis, and volleyball.

Prior to joining the NCAA, the Nittany Lions were members of the United States Collegiate Athletic Association (USCAA) and competed in the Pennsylvania State University Athletic Conference (PSUAC) until after the 2023–24 academic year.