Penns Creek is a 67.1-mile-long (108.0 km)[1] tributary of the Susquehanna River in central Pennsylvania in the United States.
Between 1754, when the Iroquois sold most of the Susquehanna Valley including the creek to the provincial government of Pennsylvania, and 1772, it was called both Big Mahany and John Penn's Creek (after the younger brother of Pennsylvania founder William Penn) by the European settlers who moved there.
[4] Penns Creek drains a watershed of approximately 163 square miles (420 km2) in Snyder, Union, and Centre counties.
It flows from its headwaters north of Spring Mills to the Susquehanna River, approximately 3.6 miles (5.8 km) downstream of Selinsgrove.
Farming, surface mining, wastewater treatment facilities and industrial spills are cited as contributing factors to loss of water quality.