In 2006, when it was still located in northeastern Pennsylvania, the 10th district experienced one of the greatest party shifts among all House seats that switched party control: in 2004, Republican Don Sherwood won with an 86% margin of victory over his nearest opponent and two years later, Democrat Chris Carney unseated Sherwood by a 53%–47% margin.

In 2016, local businessman and former mayor of Lewisburg, Mike Molesevich challenged Marino for the seat, but he fell to the Republican in November by more than two to one.

As for the educational attainment of potential voters in the district, 9% of those 25 and older have not earned a high school diploma, while 30% hold a bachelor's or higher degree.

The district encompassed the following counties and areas:[7][8] On June 8, 2012, The Pennsylvania Legislative Reapportionment Commission adopted a revised final redistricting plan.

Originally, no Democratic candidates filed to run for office, upon this revelation, Mike Molesevich, an environmental contractor and former Lewisburg mayor, announced he would seek a write-in campaign to get on the general election ballot.

[18] Jerry Kairnes of Lycoming County announced that he would seek to be on the November ballot as an Independent, but dropped out after Molesevich earned a spot on the ballot[19] Among the Democrats who have announced their intentions to challenge Perry are Pennsylvania businessman John Broadhurst, WITF senior vice president and director of community policing for the Harrisburg Bureau of Police Blake Lynch, former WGAL-TV anchor Janelle Stelson, retired Marine Mike O'Brien, retired soldier Rick Coplen, and Harrisburg city councilor Shamaine Daniels.