PA 127 begins at an intersection with US 62 in Hickory Township, Forest County, heading west on two-lane undivided Main Street.

The route immediately crosses the Allegheny River into the residential community of West Hickory in Harmony Township.

Along this stretch, PA 127 forms the west border of the Allegheny National Forest.

Here, PA 127 passes homes before turning south onto Buckingham Street and running past businesses.

The route crosses the Allegheny River again into Limestone Township and immediately ends at US 62.