From here, the route heads into a rural area of northern Lawrence County that is home to an Amish community.

As PA 208 enters Mercer County, it turns east-northeast and meets US 19 at the village of Leesburg about 1.7 miles (2.7 km) later.

About 3.5 miles (5.6 km) from Leesburg, the route is joined by PA 258 north of the Grove City Premium Outlets, and the concurrency then interchanges with I-79 (exit 113) immediately thereafter.

The concurrency meets the northern terminus of PA 268 about 1.6 miles (2.6 km) later in the borough, and turns north to cross the Allegheny River.

The westbound interchange ramps are 0.3 eastward on the PA 38/PA 208 concurrency, which continues northeasterly to the county line 0.3 miles (0.48 km) later.

After crossing into Clarion County a second and final time, the PA 38/PA 208 concurrency continues north-northeastward 1.2 miles (1.9 km) before its northern terminus.