The road passes through a mix of farmland and woodland with some homes, crossing into West Donegal Township.

The road crosses the creek again and passes to the east of the large Masonic Village retirement community.

PA 241 heads into the borough of Elizabethtown and becomes West Bainbridge Street, soon turning northwest onto Masonic Drive.

Gretna Road, heading through wooded residential areas before coming to a bridge over the PA 283 freeway.

The road continues through rural residential areas with woods to the northwest and farms to the southeast before winding north through forests.

The route curves northeast and runs through a mix of farm fields and woods with some homes, passing through the community of Bellaire.

The road continues northeast through farmland with some homes and comes to a bridge under the Pennsylvania Turnpike (Interstate 76).

Here, the route runs through a mix of fields, woods, and homes before it crosses the Conewago Creek again and comes to an intersection with PA 117 in the community of Colebrook.

The route enters North Cornwall Township and curves northeast as it continues through farmland with some residential development.

[9] The northern terminus was moved to its current location in the 1950s following the rerouting of PA 72 to Quentin Road.

[10][11] The southern terminus of the route was cut back to its current location at PA 441 near Bainbridge in 1961.