Commissioned in 1928, the designation began at U.S. Route 309 (US 309) in Slatington, east to PA 45 in Berlinsville.

It headed eastward along Mountain View Drive (modern Main Street) and crossed the Lehigh River to enter the borough of Walnutport in Northampton County.

Outside of Walnutport, PA 245 traversed Lehigh Township on a northeasterly alignment.

At this time, PA 245 was paved from Slatington to just east of Walnutport.

A portion of Main Street in Lehigh Township has been severed with the construction of Mountain View Drive as the road connecting Walnutport to PA 248.