It runs 2.10 miles (3.38 km) from U.S. Route 22 Business (US 22 Bus.)

The route runs through a suburban area of Pittsburgh.

PA 791 heads north from the southern terminus on Rodi Road, passing through suburbs.

and as part of the Yellow Belt[3] Shortly after the intersection, it heads under Interstate 376 and receives traffic from exit 80.

Two miles to the north, it ends at PA 380 in Penn Hills at a shopping plaza.