Although it is signed east–west, the route takes a more northeast–southwest direction, especially in Indiana and Clearfield counties.

The route starts at an interchange at US 22 in a rural portion of the municipality of Monroeville and continues into Plum Borough.

Before entering the borough of Indiana, the route has an intersection with PA 217 outside of the village of Jacksonville, where it terminates.

The route enters the borough from the southwest, and has a short concurrency with PA 954 in downtown.

Following a short concurrency with PA 403 in Clymer, and an intersection with PA 240 in the village of Commodore, the route continues northeast, passing through Glen Campbell It then crosses the Clearfield county line after spending about 50 miles in Indiana County.