U.S. Route 219 (US 219) is a part of the U.S. Highway System that runs from Rich Creek, Virginia, to West Seneca, New York.

[2] US 219 enters Pennsylvania from Maryland in Elk Lick Township, Somerset County, heading north as a two-lane undivided road through rural areas of farmland and woodland.

[1][3] US 219 crosses the Stonycreek River into Cambria County and heads near suburban residential and commercial development southeast of Johnstown, coming to an interchange with PA 56.

The freeway heads into more rural areas of woods with some farms and reaches an interchange with PA 869 near the Johnstown Flood National Memorial.

From here, US 219 continues through wooded areas to the west of Ebensburg, coming to an interchange with the eastern terminus of the western segment of US 422.

After this, US 219 begins to follow the West Branch Susquehanna River and curves to the north again, passing through forests and intersecting PA 240.

[1][3] US 219 continues into Clearfield County and passes through more forested areas, running through Burnside and coming to an intersection with PA 286.

The road continues northeast alongside the West Branch Susquehanna River and comes to a junction with PA 36, heading east concurrent with that route.

South of DuBois, US 322 splits from US 219 by heading to the west and US 219 continues northwest to an intersection with the northern terminus of US 119, turning north at this point.

The route heads into developed areas of homes and businesses in DuBois, widening into a five-lane road with a center left-turn lane as it approaches the intersection with PA 255.

Here, US 219 turns west onto a three-lane road with a center left-turn lane and passes through more developed areas of the city.

The road leaves DuBois and heads through more rural areas with some development, widening into a four-lane divided highway and intersecting PA 830 before coming to an interchange with I-80.

Past Ridgway, the route winds northeast through more forested areas alongside the Clarion River and reaches Johnsonburg, where it intersects PA 255 again.

In 2013, with a larger allocation of Federal level funding, construction restarted on the US 219 Freeway starting between Meyersdale and Somerset.