The route heads into residential areas and turns northeast onto Wampum Road, passing over the CSX line before crossing the Beaver River into Wayne Township.

The road continues between farmland to the northeast and woods, along with the P&W Subdivision, the Youngstown Line, and the Beaver River, to the southwest.

[1][2] The route curves south into forested areas, turning east to head away from the river and railroad lines and pass through the residential community of Rock Point.

The road heads south through residential areas, passing over the P&W Subdivision line as a two-lane divided highway before becoming undivided again intersecting the eastern terminus of PA 351.

[1][2] PA 65/PA 288 continues into Beaver County, passing through more industrial sections of Ellwood City before running through urban residential areas and widening into a four-lane divided highway.