PA 410 begins at an intersection with US 119 in Henderson Township, Jefferson County, heading east on a two-lane undivided road.

[2][3] PA 410 enters Brady Township in Clearfield County and becomes Main Street, heading east through more farms and woods with some residences.

The road crosses into the borough of Troutville and turns northeast, passing homes.

The route heads back into Brady Township and runs through more agricultural areas with some residences, turning east onto Shamokin Trail.

PA 410 continues northeast through a mix of farmland and woodland with some homes before ending at an intersection with US 219/US 322 in the community of Luthersburg.