PA 419 begins at an intersection with US 322 (Horseshoe Pike) in West Cornwall Township, Lebanon County, heading east on two-lane undivided Main Street.

The road continues into the borough of Cornwall and becomes Freeman Drive, running through a mix of farmland and woodland with some homes.

The two routes cross PA 501 (Stiegel Pike) and continue east through residential areas with some businesses.

[4] PA 419 enters Heidelberg Township in Berks County and heads northeast through farmland on Newmanstown Road.

The route turns north and crosses into the borough of Womelsdorf, where it becomes South 2nd Street and is lined with homes.

The route runs past residences and commercial establishments before it reaches a junction with US 422 (Conrad Weiser Parkway) in an area of businesses.

PA 419 crosses Little Swatara Creek into Bethel Township and intersects Old Route 22 before it reaches an interchange with I-78/US 22 near a few businesses.

Past this interchange, the road passes near farm fields and homes in Schubert before it enters forested areas at the base of Blue Mountain.

At this time, the roadway was paved in Millcreek Township, while an unpaved road continued south to Schaefferstown and north to Legislative Route 149 in Womelsdorf.

[11] By 1960, PA 83 was shifted east to a new alignment through Strausstown, leaving the road between Rehrersburg and north of Schubert unnumbered.