PA 83 was realigned to a more direct route in northern Berks County by 1960, bypassing a jog to the west through Rehrersburg.

Past the concurrency with US 422 Bus., PA 183 heads west on the two-lane undivided Washington Street, passing to the north of Reading Area Community College.

Front Street heads north while Schuylkill Avenue angles northwest, with the one-way pair continuing through areas of homes and passing over Norfolk Southern's Harrisburg Line #2.

[3][4] The roadway passes commercial establishments before coming to a bridge over Norfolk Southern's Reading Line, at which point it enters residential areas.

A short distance later, the route enters Bern Township and becomes Bernville Road, passing through a golf course before heading past a mix of homes and businesses in Greenfield Manor.

The road passes to the south of Reading Regional Airport, gaining a center left-turn lane before heading past industrial parks and to the northwest of Penn State Health St. Joseph hospital.

[3][4] Past the US 222 interchange, the route narrows back into a two-lane undivided road and passes businesses and homes in Leinbachs.

The route passes through Pleasant Valley and heads to the north of Blue Marsh Lake along the Tulpehocken Creek, curving to the northwest.

Past Blue Marsh Lake, PA 183 enters the borough of Bernville and passes to the west of residential and commercial development in the town.

[3][4] PA 183 enters Upper Tulpehocken Township and heads northwest again through more rural areas of farms and woods as an unnamed road.

[3][4] At the summit of Blue Mountain, PA 183 widens into a four-lane divided highway, crossing the Appalachian Trail and entering Wayne Township in Schuylkill County.

The road narrows to two lanes and continues north through wooded areas with some farm fields and residences, coming to an intersection with PA 895 in Summit Station.

The route narrows back to two lanes before it crosses into North Manheim Township and becomes Chestnut Street, where it curves to the east.

[3][5] At this point, PA 183 heads into residential areas before crossing under a bridge carrying a Reading Blue Mountain and Northern Railroad line.

A short distance before passing under the railroad, PA 183 Truck splits to the north to bypass the low-clearance underpass.

PA 183 Truck turns north onto Beckville Road and heads east, crossing the railroad tracks at-grade.

The route turns northeast and crosses over the West Branch Schuylkill River before it comes to an intersection with PA 901.