At this point, the route becomes concurrent with PA 45 Truck and narrows to two lanes as it heads northwest through more open farmland with occasional woods.

[2][3] PA 453 continues into Snyder Township in Blair County as an unnamed road and passes to the south of a quarry, crossing the Little Juniata River.

The road heads to the northeast of the Norfolk Southern railroad line and crosses the river again, coming to an intersection with PA 550.

At this point, the route turns north to form a concurrency with US 220 Business on two-lane undivided Pennsylvania Avenue, passing a mix of homes and commercial establishments.

[2][4] PA 453 enters Gulich Township in Clearfield County and continues west through more forests, eventually turning northwest again.

The two routes continue north-northeast through more woods with scattered farm fields, becoming Main Street and heading into the borough of Ramey.

The route passes through more residential areas of the town before heading into Bigler Township in the community of Beluah and turning southwest to follow Jimmies Hill Road through a mix of farmland and woodland.

The route heads into residential areas, turning northeast and passing over Anderson Creek and under another R.J. Corman Railroad line.