For years, a gap existed in PA 60 between West Mayfield and New Castle; it was filled on November 20, 1992, with the opening of a toll road between the two locations.

The route veers southward here, remaining on Bradford Avenue to a junction with Crafton Boulevard, where it rejoins opposing traffic.

[3][4] Once again a two-direction highway, PA 60 heads westward through a more open but still developed area of Crafton before exiting the borough upon crossing over Chartiers Creek and a Pittsburgh and Ohio Central Railroad line.

At this point, the Yellow Belt joins PA 60 as the route heads generally westward through a narrow but extensive commercial and residential neighborhood developed around the highway.

As the route enters the vicinity of I-376, US 22, and US 30, the valley widens and the homes and small commercial developments give way to larger establishments and stores.

[6][9] Construction began in the 1960s on the Beaver Valley Expressway, a north–south freeway extending from Pittsburgh International Airport to Sharon via New Castle.

[8][10] The segment of the freeway between Clinton Road northwest of the airport and Beaver was completed by the following year.

Also completed by this time was the New Castle – Sharon segment of the highway, which was also designated as PA 60 upon opening.

On October 20, 1989, ground was broken on a bridge over the Mahoning River in Lawrence County, marking the start of a $260 million project to complete the missing link in the freeway.

The highway, built by the Pennsylvania Turnpike Commission as a toll road, opened to traffic on November 20, 1992.

[20] Meanwhile, ground was broken August 27, 1990, on the Southern Expressway, a $190 million, 7.5-mile (12.1 km) highway built to serve a new terminal at Pittsburgh International Airport.

[23] It was extended again on November 6, 2009, to Interstate 80 near Sharon, overlapping US 22 and US 30 along the Parkway West and replacing PA 60 from Steubenville Pike north to I-80.