The freeway comes to an interchange with Interstate 376 (I-376), where US 22/US 30 heads southeast concurrent with I-376 and PA 60 continues east (south) at-grade along a four-lane divided highway.

[2][3] The four-lane freeway heads east-southeast between Downtown Pittsburgh to the north and the Monongahela River to the south, reaching a partial interchange with Stanwix Street with no eastbound exit.

[2][3] US 30 enters Westmoreland County in the Laurel Highlands region and continues south along the four-lane undivided Lincoln Highway, curving southeast and passing through Stewartsville.

Farther east, the route runs through rural areas with some development, passing to the north of Arnold Palmer Regional Airport as it widens to six lanes and comes to an intersection with PA 981 to the south of Latrobe.

At this point, the road heads east as a four-lane divided highway with the Loyalhanna Creek parallel to the south, passing to the north of the Idlewild and Soak Zone amusement park.

[2][3] Past Stoystown, US 30 crosses the Stonycreek River and intersects the southern terminus of PA 403 before it comes to a bridge over CSX Transportation's S&C Subdivision railroad line.

The road makes a hairpin turn to the southeast and winds east, coming to an eastbound truck brake check station as it continues to descend.

[2][3] US 30 heads east-northeast a short distance to the south of the Pennsylvania Turnpike and reaches a junction with the eastern terminus of PA 56 before it curves southeast and crosses the Raystown Branch Juniata River in Wolfsburg.

The route leaves Bedford and crosses the river again before it comes to a westbound exit and eastbound entrance with the eastern terminus of US 30 Bus., where the freeway section ends and US 30 becomes the four-lane divided Lincoln Highway.

US 30 narrows to three lanes as it continues through a mix of rural areas and development, passing south of Fayetteville before it forms a short concurrency with PA 997 upon intersecting that route in Greenwood.

US 30 enters Gettysburg and becomes Buford Avenue, passing north of United Lutheran Seminary as it heads into developed areas and turns east onto Chambersburg Street.

US 30 heads east-northeast as West Market Street, a five-lane road with a center left-turn lane, and turns into a four-lane divided highway as it comes to a junction with the northern terminus of PA 616.

US 30 widens to six lanes before the freeway section ends, with US 30 becoming a six-lane divided highway with at-grade intersections called Loucks Road that passes development.

US 30 continues east-northeast and passes north of the Haines Shoe House as it heads into rural areas, coming to a diamond interchange with Kreutz Creek Road that provides access to PA 462 and Hallam to the south.

US 30 leaves Lancaster as it passes over Amtrak's Keystone Corridor and Norfolk Southern Railway's Lititz Secondary railroad lines, reaching an eastbound exit and westbound entrance with PA 72.

The freeway curves to the south-southeast, passing over Norfolk Southern Railway's New Holland Secondary and Amtrak's Keystone Corridor railroad lines before coming to a partial interchange with PA 340 that has no westbound exit.

[2][3] Past the interchange with the eastern terminus of PA 462, US 30 heads east-southeast along Lincoln Highway, a five-lane road with a center left-turn lane, passing through Greenland.

US 30 passes south of the Willow Hill Covered Bridge and American Music Theatre and runs between two shopping centers before it reaches an intersection with PA 896.

Past this intersection, the route narrows to a three-lane road with a center left-turn lane and heads through agricultural areas with some development, passing through Soudersburg.

US 30 splits from the Lincoln Highway at an eastbound exit and westbound entrance by heading onto a four-lane freeway called the Coatesville Downingtown Bypass, with US 30 Bus.

Past this intersection, the road crosses under Norfolk Southern Railway's Dale Secondary railroad line and continues east as it runs north of Malvern, becoming undivided.

US 30 briefly gains a center left-turn lane before it becomes a divided highway again as it passes south of Paoli Hospital prior to crossing under Amtrak's Keystone Corridor railroad line to the north of Green Tree.

[2][3] Upon intersecting Old Eagle School Road/Sugartown Road, US 30 enters Delaware County and continues east-southeast along four-lane undivided Lancaster Avenue, curving east and running through the downtown area of Wayne.

Past this interchange, the route turns back into an undivided road and crosses under SEPTA's Norristown High Speed Line before coming to an intersection with PA 320 in Villanova.

At the intersection with 62nd Street/Malvern Avenue, the route passes north of 63rd Street and Malvern Avenue station that serves as the terminus of SEPTA's Route 10 trolley line and heads into urban areas of West Philadelphia a short distance to the south of Amtrak's Keystone Corridor railroad line, running north of Overbrook High School after the 59th Street intersection.

From this point, I-676/US 30 crosses over I-95, Christopher Columbus Boulevard, and then the Delaware River into New Jersey on the seven-lane Benjamin Franklin Bridge, which also carries pedestrians and the PATCO Speedline.

[7] The path of the Lincoln Highway was first laid out in September 1913; it was defined to run through Canton, Ohio; Beaver, Pittsburgh, Greensburg, Ligonier, Bedford, Chambersburg, Gettysburg, York, Lancaster, and Philadelphia, Pennsylvania; and Camden, New Jersey.

[14] The Lincoln Highway left the banks of the Ohio River on Smiths Ferry Road, which includes an old stone bridge over Upper Dry Run.

[citation needed] US 22 and US 30 now join I-376 and turn southeast, but the Lincoln Highway (and US 22/US 30 before the nearby part of what is now I-376 opened in 1953) continued east with PA 60 through Robinson Township.

[citation needed] White Oak named their main street Lincoln Way in an attempt to convince the LHA to use it, but instead the highway continued along Greensburg Pike through North Versailles Township.