PA 624 is a two-lane undivided road that runs through rural areas in eastern York County.

PA 624 continues northeast before it turns north and follows the western bank of the Susquehanna River to Wrightsville.

From the southern terminus, the route heads northeast on two-lane undivided East High Street, passing homes.

The road crosses into Lower Windsor Township and reaches the residential community of Bittersville, where it turns north before curving back to the northeast.

PA 624 turns west away from the Susquehanna River and heads through fields with some trees, curving back to the north.

The route continues into the borough of Wrightsville and becomes South Front Street, curving west before turning northwest and crossing the Kreutz Creek as it heads into residential areas.

By this time, PA 224 was paved between Red Lion and Windsor and a short distance to the south of Wrightsville.