The route runs through rural areas in the Pennsylvania Dutch Country of northeastern Lancaster County, passing through Bowmansville.

[2][3] The route passes through the Pennsylvania Dutch Country of eastern Lancaster County, which is home to many Amish farms.

[4][5] The road heads through agricultural areas with some homes, passing to the east of an industrial complex before crossing the Conestoga River.

The route curves northeast through more farmland with a few trees and residences and turns north to cross Black Creek into Brecknock Township.

The route runs through a mix of farms, trees, and residential and commercial development to the east of parallel Muddy Creek, curving to the northeast.

[2][3] PA 625 enters Brecknock Township in Berks County and becomes New Holland Road, crossing Muddy Creek and passing through forested areas with some homes.

PA 625 curves northeast and becomes parallel to Angelica Creek, running through wooded areas with some homes and passing to the east of a golf course.

Past this intersection, PA 625 enters the borough of Kenhorst and passes businesses before it continues north through residential and commercial areas.