Past the Reading area, PA 724 continues southeast parallel to the Schuylkill River, passing through or near Birdsboro, Pottstown, and Spring City.

PA 724 begins at an intersection with US 422 near the city of Reading in the borough of Sinking Spring, Berks County, heading southeast on two-lane undivided Shillington Road.

The route gains a center left-turn lane and crosses into Spring Township, where it heads through residential areas with some commercial establishments.

PA 724 widens into a four-lane divided highway and runs past businesses, turning south into Cumru Township to intersect US 222 Bus.

Past this, the route crosses Angelica Creek and fully enters Cumru Township again, passing through the residential community of Grill.

The route comes to an interchange with I-176 and passes southeast through the community of Ridgewood, where it crosses the Schuylkill River Trail and Norfolk Southern's Harrisburg Line #1.

The road heads east-southeast through a mix of fields and trees with some homes along the north side of the Norfolk Southern line and a short distance south of the Schuylkill River.

Farther east, PA 724 passes through wooded areas before it enters the borough of Birdsboro, where it runs past residences and industrial development on West Main Street.

The road passes through a golf course and runs through the community of Kenilworth, where it intersects a ramp that provides access to the US 422 freeway to the north at a trumpet interchange.

The route passes through the community of Parker Ford, where it intersects Linfield Road/Bethel Church Road, and briefly runs to the southwest of the Schuylkill River Trail before it enters East Vincent Township.

PA 724 continues past a mix of residences, businesses, and farm fields, turning to the south and coming to a junction with New Street, which also provides access to Spring City.

Daryl Hall, a Pottstown native, and John Oates approached Talmadge W. Faulk at his restaurant Toggs on PA 724 on the eastern outskirts of town.

The Rosedale Diner remained in the same spot until it was scrapped in 1983, due to the dilapidated condition it had incurred at the hands of souvenir-hunting Hall & Oates fans.