The route is a two-lane road its entire length, passing through the community of Warwick, Hopewell Furnace National Historic Site, French Creek State Park, and the borough of Birdsboro.

The route crosses into East Nantmeal Township and passes woodland and homes, curving north to reach an intersection with PA 401.

PA 345 turns north onto Pine Swamp Road and heads into a mix of farmland and woodland with some homes.

[2][3] PA 345 winds northeast into forested areas and enters Union Township in Berks County, where it heads through the Hopewell Furnace National Historic Site and crosses French Creek.

The road curves to the northwest and continues into French Creek State Park, running through more dense forests.

The route leaves the state park and winds north through the community of Kulptown, with the name changing to Chestnut Street.