The route is mostly a two-lane road that passes through rural areas of the Pennsylvania Dutch Country to the north of the city of Lancaster.

From here, the route heads northeast on two-lane undivided Anderson Ferry Road, passing through agricultural areas with some trees and homes.

PA 772 heads into the borough of Mount Joy and becomes Marietta Avenue, running past multiple homes and turning to the east-northeast.

The route passes over Amtrak's Keystone Corridor railroad line east of Mount Joy station before it comes to an intersection with PA 230.

The road continues northeast through agricultural areas with occasional development, coming to the residential community of Sporting Hill.

PA 772 splits from Fruitville Pike by turning northeast onto Temperance Hill Road, heading through agricultural areas and bending southeast.

PA 772 continues into the borough of Lititz and passes south of Warwick High School, running past more homes.

The route continues as a two-lane undivided road past more of the downtown before it heads into residential areas, passing north of the Linden Hall boarding school.

[2][3] PA 772 leaves Lititz for Warwick Township again and heads southeast past a mix of homes and businesses, becoming Rothsville Road.

Past this intersection, the road becomes a four-lane divided highway and reaches a partial cloverleaf interchange with the US 222 freeway.

[2][3] At this point, the route enters the Pennsylvania Dutch Country of eastern Lancaster County, which is home to many Amish farms.

[4][5] The route heads south as a two-lane undivided road and runs through the community of Brownstown, where it passes homes and a few businesses along State Street.

The route turns south and passes through the community of Center Square, at which point it enters Upper Leacock Township.

The road continues through rural land before heading into the community of Leacock, where it passes homes and a few businesses before coming to PA 23.

The road crosses Norfolk Southern's New Holland Secondary at-grade and continues through a mix of farmland and industrial and commercial development, bending southeast.

The route widens to a four-lane divided highway and comes to an incomplete interchange with the unbuilt Goat Path Expressway, with a bridge over the right-of-way.

The route heads southeast and enters the community of Intercourse, where it passes residences and turns south to an intersection with PA 340.

The road leaves Intercourse and runs through agricultural land with scattered residences, heading southwest of Pequea Valley High School.

The route crosses Pequea Creek into Salisbury Township and continues through rural areas, passing through the community of Buyerstown.