Additionally, the Bay Center has served as the host venue of the Sun Belt Conference men's and women's basketball tournaments since 2021.

Bon Jovi performed to the arena's largest crowd ever for a concert on February 4, 1989 as part of their Jersey Syndicate Tour.

The tour's dress rehearsal at the Pensacola Civic Center issued 7,600 tickets to the public as a benefit to local charity, which sold out in less than an hour.

KISS was the first band to perform at the arena, and continues to make Pensacola a destination on its North American tours.

This show is notable because it was the first show Yes played with the 8 man line up of Jon Anderson, Chris Squire, Steve Howe, Rick Wakeman, Alan White, Bill Bruford, Trevor Rabin and Tony Kaye, which was inducted into the Rock and Roll Hall of Fame in 2017.

Many other large touring acts, including Gloria Estefan, AC/DC, Page & Plant, David Bowie, Rush & Van Halen have used the arena for pre-tour rehearsals in the past, thanks to the venue's relatively inexpensive rental rates and availability for extended occupation.

On March 9, 1994, the Pensacola Bay Center hosted the largest Rock for Choice concert in history, which was organized by the band L7 and headlined by Pearl Jam.

During the 2008 presidential race, both Sarah Palin and Michelle Obama used the venue for political rallies as the November election drew close.