The Centreplex quickly became Central Georgia's premier sports, entertainment and trade show venue, with concerts by well-known performers such as Elvis Presley.

Many others have performed here, including Led Zeppelin, the Allman Brothers Band, KISS, Van Halen, Jethro Tull, James Brown, War, Jackson 5, Jeffrey Osborne, Earth, Wind, and Fire, The Emotions, Bar Kays, Parliament/Funkadelic, The Temptations, OJays, Chicago, Leon Russell, Aerosmith, Rick James, Prince, The Time, Vanity 6, George Jones, Reba McEntire, Kenny Rogers, Hank Williams Jr., Red Hot Chili Peppers, Sarah McLachlan, Billy Joel, Katy Perry, Elton John and many others.

World Championship Wrestling (WCW) was a frequent visitor of the Centreplex, holding multiple television tapings and non-televised house shows all throughout the 90s.

WCW Monday Nitro, WCW's flagship weekly live television show that aired on TNT, emanated from the Centreplex a few times: — November 20, 1995 (notable for featuring the first one-on-one match in history between Hulk Hogan and Sting)[2] — May 27, 1996 (notable for being the first two-hour episode of the show and Scott Hall's debut in WCW, beginning the New World Order storyline)[3] — December 23, 1996[3] — June 23, 1997[4] — December 22, 1997 (notable for being the first and only episode of "nWo Monday Nitro")[4] WWE also visits the Centreplex.

On January 28, 1991, the company (then called the World Wrestling Federation or "WWF") held their 5th and final episode of The Main Event V, which aired nationally on NBC on February 1, 1991.

The Macon Coliseum was used to stand for La halle de glace Olympique in Albertville and the CC Amfi in Hamar in the film I, Tonya.