The most remarkable success of the PC-22 was the 1993 Indianapolis 500 win by Fittipaldi, placed 2nd at the end of the season, missing the championship by only 8 points.

In Indianapolis, Fittipaldi qualified 9th (220.150 mph),[2] and won the event exploiting Mansell's inexperience on oval racing and Andretti's handling problems, after their dominating runs.

After two races, Milwaukee and Detroit, with only one podium finish, the Penske come back to victory in Portland, with Fittipaldi 1st and Tracy 3rd.

Tracy won at Road America and Fittipaldi at Mid-Ohio, but Mansell clinched the title with his 5th season win at Nazareth.

It won both the 1994 CART season, and the 1994 Indianapolis 500 with Al Unser Jr., together with Emerson Fittipaldi and Paul Tracy scoring 12 wins out of 16 in total,[5] collecting 10 pole positions and 28 podium finishes, in a season that saw Penske also take the Constructor's Cup, and the Manufacturer's Cup with the Ilmor-Mercedes-Benz engine.