[3] Pepin County is the birthplace of Laura Ingalls Wilder, the author of the Little House on the Prairie children's books.

The lake itself is likely named for one or more of the Pepin families from the French Canadian city of Trois-Rivières in Quebec, Canada.

Several Pepins appear in the early records, including the senior figure Guillaume dit Tranchemontagne and his descendants Pierre and Jean Pepin du Chardonnets.

One or both of the latter may have accompanied Daniel Greysolon, the Sieur du Lhut, from Montreal to what is now Duluth, Minnesota, in 1679.

26.10% of all households were made up of individuals, and 13.60% had someone living alone who was 65 years of age or older.

[12] Additionally, there were no reported induced abortions performed on women of Pepin County residence in 2017.

[14] Prior to the election of Donald Trump in 2016, the last time Pepin County voted for the Republican candidate was in 1972, when voters backed President Richard Nixon (R) over George McGovern (D).