Brahe was the son of Joakim Brahe (died 1520 in the Stockholm Bloodbath) and Margareta Eriksdotter Vasa, the sister of Gustav Eriksson Vasa, who became King of Sweden in 1523.
Brahe was thus the cousin of three future kings, Eric XIV, John III and Charles IX, all of them sons of Gustav Vasa.
He had been member of the Privy Council of Sweden and Governor of Stockholm Castle from 1540.
Brahe's mother-in-law was the daughter of Erik Abrahamsson Leijonhufvud and Ebba Eriksdotter Vasa, the mother of Gustav Vasa's second wife, Margaret Eriksdotter Leijonhufvud.
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